NMN has gradually been accepted by the public from rare high-end health food

Every friend hopes to have a healthy body and strong energy, so that they can live happily and want to live a long life. So at this time, we need to use NMN. This magical substance has gradually become a topic of discussion at the dinner table. So what is the efficacy and role of NMN? Let's talk about it with you.

NMN is the abbreviation of Nicotinamide mononucleotide, with a molecular weight of 334.2192. It is an inherent substance in the human body and is also rich in some fruits and vegetables. According to the FDA's equivalence principle, a 70Kg adult should supplement 600mg of NMN per day, and an adult supplementing the same amount of NMN needs to eat 32~128kg of edamame, or 54~240kg of broccoli. And this is still in the case of ensuring complete absorption, which is obviously unrealistic, and it is particularly important to supplement NMN from non-food sources.

NAD+ has a fundamental impact on human health, but with age, the content of NAD+ in the human body gradually decreases, the communication between mitochondria and nucleus is impaired, and the reduction of NAD+ also impairs the ability of cells to generate energy, resulting in Aging and disease, which may also be why we age.

However, the difficulty is that NAD+ cannot be directly orally taken into cells for supplementation due to its large molecular weight. The supplementation of NAD+ can only be achieved by ingesting NAD+ precursors of smaller molecular weight. Over the next few years, the Sinclair lab at Harvard University and the Shinichiro Imai lab at the University of Washington independently confirmed that oral intake of a naturally occurring NAD+ precursor, NMN, can effectively improve blood, skin, and NAD+ content in various organs of the body, such as muscle, heart, and brain, and significantly inhibit the decline of metabolism and weight gain caused by aging. Not only that, the ATP levels in the aged animals given NMN also returned to the level of the young animals.

Studies have shown that NMN is absorbed very quickly in the body and can rapidly increase NAD+ levels in the body:
A, absorbed through the digestive system intact;
B, 2~3 minutes into the blood;
C, increase the NMN content in the tissue within 15 minutes;
D, rapidly increase the NAD+ level in the blood, liver and other organs;

Secondly, what we want to talk about is the anti-aging ability of NMN, which can effectively improve memory and improve sleep quality. Second, DNA repair, supplemented with enough NMN, can greatly repair the DNA of irradiated cells, suitable for patients with radiotherapy and chemotherapy, and people exposed to radiation. Third, enhancing disease resistance can effectively intervene in diabetic patients with poor diet and drug control. Third, it can effectively improve neurocognition, including Parkinson's syndrome, Alzheimer's disease, etc. Fourth, it protects the cardiovascular system, because it can increase the level of NAD+ in the heart and reduce the damage to the heart. Fifth, it can effectively protect the liver and hangover, and effectively enhance the tolerance of the human liver to alcohol. Sixth, it can effectively protect vision and hearing, and effectively protect the retina from damage. NMN can prevent photoreceptor cell degeneration and increase the sensitivity of ear neurons.

From 2016 to 2018, top scientific research institutions such as Harvard University, University of Washington, Keio University in Japan respectively reversed muscle atrophy and improved physical fitness; inhibited cognitive decline caused by aging; reversed vascular death and protected cardiovascular and cerebrovascular functions. The anti-aging effects of NMN were evaluated in detail. The results consistently show that NMN has a full range of significant effects in inhibiting aging. For example, in the latest research report published in Cell in March 2018, NMN successfully reversed muscle atrophy and vascular death in aged animals, and greatly enhanced the vitality of animals. The physical strength of aged animals taking NMN exceeded 60% of animals of the same age above. The most surprising thing is that the NAD+ recovery brought about by oral administration of NMN can extend the lifespan of experimental animals similar to humans by more than 30%.

These discoveries made NMN quickly become the focus of research in the field of aging medicine. In just a few years, nearly 100 papers have been published in authoritative academic journals such as "Cell", "Nature", and "Science". elaborate.

Since then, NMN has been officially recognized as the world's first natural substance that has been proven by rigorous scientific experiments to effectively reverse and delay aging and prolong life.
Based on the DNA repair effect of NMN, NASA (NASA) has begun to study its use in protecting astronauts from cosmic rays in 2017. Previous research has shown that DNA damage to astronauts caused by high-energy particle radiation in space can cause 5% of the body's cells to die, significant aging, and almost 100% of cancer after a four-year round trip to Mars. And NMN is expected to be the key to solving this challenge.



Such magical effects have naturally aroused strong attention from all parties to NMN, but it is a huge challenge to commercialize it. The most immediate obstacle is that the complexity of its production technology makes it extremely expensive. Therefore, NMN was only sold to research institutions as a scientific research material in the past. For example, Sigma-Aldrich, a subsidiary of the German pharmaceutical giant Merck, publicly quoted NMN at RMB 10,682.10 per 500 mg (June 2018). Even if the minimum effective dose of 6,000 mg per month is calculated, the annual cost per person will be as high as 1.56 million yuan. Therefore, NMN has only existed in the past few years as a luxury that some people with special status and scientists involved in related research have the opportunity to take. Secondly, the absorption efficiency and stability of NMN are difficult to control, and the formulation design of oral products and the entire production process and storage and transportation environment are extremely demanding.

Since then, he has come from many well-known biotechnology companies in the world, such as Reinvigorator (Reinvigorator), AAGQ (Anjianqi), Mkule McKenryer, GeneHarbor, etc., and has long been focusing on genetic anti-aging research and high-level research and development of anti-aging products. Technology companies, upgrading the enzyme-directed catalysis technology on the basis of the original production process, increased the output of NMN active ingredients by more than 30%, reduced the cost by more than 90%, and achieved a purity of 99.9%, which has been recognized by consumers around the world, especially in China. The elderly love it, allowing more consumers to have the opportunity to enjoy the benefits brought by cutting-edge biotechnology, creating a historical precedent for NMN products and opening up a new era for the NMN industry.