NMN (Nicotinamide Mononucleotide) -- embarking on a cellular journey through time and space

NMN (Nicotinamide Mononucleotide) -- embarking on a cellular journey through time and space

Known as the "elixir", NMN has made more breakthroughs in the research on the prevention and treatment of more disease symptoms in the human body. Recently, the cardiovascular disease sub-journal of the international authoritative scientific journal "Nature" published an NMN research progress:

The article stated that the promotion of NAD+ metabolism by supplementing NMN and other precursors may become the first evidence-based therapy for HFpEF, which is expected to reduce the number of hospitalizations due to cardiovascular disease in the elderly, reduce the risk of cardiac death, and promote healthy heart aging.

NAD+ metabolism may be the first evidence-based therapy for HFpEF to reduce the number of cardiovascular hospitalizations, reduce the risk of cardiogenic death, and promote healthy heart aging.

Studies have found that mitochondrial dysfunction and decreased NAD+ biosynthesis in human cells are the key pathogenesis of diastolic heart failure. After supplementing NMN, a precursor of NAD+, to patients with heart failure symptoms, there is a significant difference in heart failure and mitochondrial function. improve.

According to the existing data, we can know that Nature, as one of the rigorous and authoritative scientific journals in the world, has published articles here to reveal the efficacy of NMN, including Harvard Medical School. Among them, the value of NMN lies in its ability to synthesize an important coenzyme in human cells - nicotinamide adenine dinucleotide, or NAD+.

NMN is valued for its ability to produce nicotinamide adenine dinucleotide, or NAD+, an important coenzyme in human cells.

 

It is reported that NAD+ is known as the "engine" to maintain human survival and health in the scientific community, and it plays an important role in gene repair and rejuvenation of young cells. However, it will stop secretion with age. Because the molecular weight of NAD+ is too large, it cannot be directly supplemented , NMN, as an important precursor that can be rapidly converted into NAD+ in the body, has become a high-quality NAD+ supplement recommended by "Nature".

The results of the first phase II clinical trial of NMN published in Science are undoubtedly exciting. The trial recruited a group of healthy elderly men over 65 years old, and the treatment group took NMN (250 mg/d) daily for 6 weeks or 12 weeks, and compared with the control group.

After taking NMN for 12 weeks in the treatment group, the NAD+ level in the blood increased significantly, and the postprandial blood glucose, insulin and C-peptide release levels of some subjects decreased significantly. Cell function enhancement. This means that subjects taking NMN have improved insulin sensitivity and improved systemic metabolic aging.

In addition, in the study, through the exercise ability test, it was found that the upper and lower limb muscle strength and walking speed of the subjects who took NMN were significantly improved, and the effect was only 6 weeks after taking it.

For up to 12 weeks, the subjects did not experience any adverse reactions, and the hematology, liver function, and renal function indicators were all normal, and even uric acid did not increase, which once again proved the safety of NMN for the human body.

In December 2021, a study jointly completed by the Chinese Academy of Sciences and Chongqing Medical University and other units successfully reversed the "telomere clock" using NMN.

The study recruited 8 healthy male human volunteers aged 45-60 years to take 300 mg of NMN supplements with warm water half an hour before breakfast every day for 90 days, during which time their telomeres "day" longer than a day." After 90 days, it reached an average of nearly twice the length before the start of the experiment.

Up to now, there have been more than 500 scientific research papers on NMN in authoritative journals around the world, and more than one million people have taken it. Humans have been unable to stop the attack of NMN.

 

AAGQ (An Jianqi), a well-known American health care brand, launched the first generation of unilateral NMN15000 capsules (priced at $350) in 2019. The purity of NMN raw materials is as high as 99.9%. It has been recognized by consumers in the United States and Europe, especially by middle-aged and elderly people. In October 2021, the company continued to increase investment in research and development, and expanded production capacity, greatly reducing production costs, and launched the industry's first ten-in-one compound NMN15000 small molecule tablet product (priced at $260). On the basis of retaining the 200mg unilateral content of NMN, coenzyme Q10, PQQ, vitamin B, casein phosphopeptide (CPP), lycopene, quercetin, calcium citrate, folic acid, zinc, and selenium were added. The compound product has been matured and put on the market. This product realizes multi-functional small molecule supplementation, which increases the absorption efficiency of the human body by 30% compared with the first-generation product. Its significance is not only anti-aging, but also on this basis. , Antioxidant, beauty and beauty, protect cardiovascular, improve immunity, promote the absorption of amino acids, protect the liver, prevent cancer and other more comprehensive functions. Therefore, it has attracted the attention of the industry. The brand maintains cooperative relations with biological scientific research institutions in Europe, Australia, Japan, etc., and looks forward to bringing more affordable and health care products to human beings in the future.